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Following endoscopic hemostasis, patients received either 80 mg esomeprazole as an intravenous infusion over 30 minutes followed by a continuous infusion of 8 mg per hour or placebo for a total treatment duration of 72 hours.

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Long-term use of these drugs has been linked to an increased risk of hip fractures, possibly because stomach acid may be needed to absorb calcium from the diet.

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One April 2015 study showed people taking proton pump inhibitors like Nexium had a “more than twofold increase” in risk for hospital admission due to acute kidney injury than those who were given the control.

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Many gastrointestinal diseases (such as inflammatory bowel disease, ulcers, and intestinal cancers) can cause GERD, but they are often easily identified, because they have other symptoms and affect different areas of the intestinal tract.

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